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《医学前沿(英文)》 doi: 10.1007/s11684-023-1011-0
关键词: Paxlovid hemodialysis SARS-CoV-2 viral load chest CT scan
Clinical characteristics of 19 neonates born to mothers with COVID-19
Wei Liu, Jing Wang, Wenbin Li, Zhaoxian Zhou, Siying Liu, Zhihui Rong
《医学前沿(英文)》 2020年 第14卷 第2期 页码 193-198 doi: 10.1007/s11684-020-0772-y
关键词: coronavirus disease 2019 severe acute respiratory syndrome-associated coronavirus maternal-infant infection newborn
Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns
null
《医学前沿(英文)》 2016年 第10卷 第2期 页码 111-119 doi: 10.1007/s11684-016-0446-y
The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 brought back memories of the occurrence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002. More than 1500 MERS-CoV cases were recorded in 42 months with a case fatality rate (CFR) of 40%. Meanwhile, 8000 cases of SARS-CoV were confirmed in six months with a CFR of 10%. The clinical presentation of MERS-CoV ranges from mild and non-specific presentation to progressive and severe pneumonia. No predictive signs or symptoms exist to differentiate MERS-CoV from community-acquired pneumonia in hospitalized patients. An apparent heterogeneity was observed in transmission. Most MERS-CoV cases were secondary to large outbreaks in healthcare settings. These cases were secondary to community-acquired cases, which may also cause family outbreaks. Travel-associated MERS infection remains low. However, the virus exhibited a clear tendency to cause large outbreaks outside the Arabian Peninsula as exemplified by the outbreak in the Republic of Korea. In this review, we summarize the current knowledge about MERS-CoV and highlight travel-related issues.
Clinical manifestations and pathogen characteristics in children admitted for suspected COVID-19
Xiaofang Cai, Hanlan Jiang, Simin Zhang, Shengying Xia, Wenhui Du, Yaoling Ma, Tao Yu, Wenbin Li
《医学前沿(英文)》 2020年 第14卷 第6期 页码 776-785 doi: 10.1007/s11684-020-0820-7
关键词: coronavirus disease 2019 pediatrics emergency retrospective investigation severe acute respiratory syndrome coronavirus 2
Middle East respiratory syndrome coronavirus: a comprehensive review
null
《医学前沿(英文)》 2016年 第10卷 第2期 页码 120-136 doi: 10.1007/s11684-016-0430-6
The Middle East respiratory syndrome coronavirus was first identified in 2012 and has since then remained uncontrolled. Cases have been mostly reported in the Middle East, however travel-associated cases and outbreaks have also occurred. Nosocomial and zoonotic transmission of the virus appear to be the most important routes. The infection is severe and highly fatal thus necessitating rapid and efficacious interventions. Here, we performed a comprehensive review of published literature and summarized the epidemiology of the virus. In addition, we summarized the virological aspects of the infection and reviewed the animal models used as well as vaccination and antiviral tested against it.
关键词: MERS coronavirus review
Sarah H. Alfaraj, Jaffar A. Al-Tawfiq, Talal A. Altuwaijri, Ziad A. Memish
《医学前沿(英文)》 2019年 第13卷 第1期 页码 126-130 doi: 10.1007/s11684-017-0603-y
关键词: Middle East respiratory syndrome coronavirus MERS-CoV pregnancy pediatrics
Early and marked up-regulation of TNF-α in acute respiratory distress syndrome after cardiopulmonary
null
《医学前沿(英文)》 2012年 第6卷 第3期 页码 296-301 doi: 10.1007/s11684-012-0219-1
Despite the technique of cardiopulmonary bypass (CPB) improved the development of modern cardiac surgery, many factors during CPB have been reported to induce acute respiratory distress syndrome (ARDS). The present study was to investigate which pro-inflammatory factors involved in the early phase of ARDS. Ten patients underwent valve replacement surgery with or without ARDS were enrolled for analysis of pulmonary function and inflammatory factors release including white blood cell (WBC), neutrophils, CD11b, CD18, interleukin (IL)-8 and tumor necrosis factor-α (TNF-α). The results demonstrated that the ratio of arterial oxygen tension/fraction of inspire oxygen (PaO2/FiO2) was greatly reduced in ARDS patients, but only the release of TNF-α was significantly increased, which was reversely correlated to the values of PaO2/FiO2. Also, the count of neutrophils adhesive to pulmonary endothelial cells was significantly increased in ARDS patients. Therefore, we concluded that TNF-α was quickly up-regulated and involved in the pathogenesis of CPB-induced ARDS via guiding primed neutrophils to pulmonary interstitium.
关键词: tumor necrosis factor-α cardiopulmonary bypass inflammation acute respiratory distress syndrome
间充质干细胞——新冠病毒肺炎相关急性呼吸窘迫综合征潜在的治疗选择
赵璇, 张毅
《工程(英文)》 2020年 第6卷 第10期 页码 1073-1075 doi: 10.1016/j.eng.2020.05.015
中药治疗新冠病毒肺炎的科学基础 Perspective
梁丽娴, 潘胡丹, 黄虞枫, 范星星, 王婉莹, 何芳, 蔡俊, 周华, 刘良
《工程(英文)》 2020年 第6卷 第10期 页码 1099-1107 doi: 10.1016/j.eng.2020.08.009
新近暴发的新冠病毒肺炎(COVID-19)已成为危害全球健康的紧急事件。现有证据表明,新冠病毒(SARS-CoV-2)与其他冠状病毒(如SARS-CoV和MERS-CoV)的基因序列具有相似性。因此, 针对现存冠状病毒的引发疾病的机制研究和在治疗SARS时所取得的经验和教训,可咨今天对抗新冠病毒引发疾病的参考。COVID-19患者的临床病理特征提示患者在病情进展过程中通常会经历五个发展阶段:大量病毒感染、免疫系统抑制、细胞因子风暴、多器官损伤及后期的肺纤维化样改变, 严重者常导致死亡。早期阻断疾病进展是取得治疗成功的关键。但是,目前尚无针对COVID-19的 特效药物或疫苗,世界卫生组织(WHO)正敦促尽快建立新型预防和治疗策略。传统中医药(TCM) 对于疫病的防治的实践已经积累了几千年的有用经验,它通过整体调节机体功能发挥疗效。在此次疫情中,中医药作为替代治疗或与西药联合使用,在疫情防控中发挥了重要的作用。本文总结了此次抗疫过程中中国国家和省级机构推荐使用的中药复方和中成药的潜在用途和治疗机制,以期发现其治疗COVID-19的潜在科学内涵。同时,整合应用多种组学及转化医学技术开展基础与临床研究有望进一步证实中药复方的治疗机制。
Clinical study using mesenchymal stem cells for the treatment of patients with severe COVID-19
Lingling Tang, Yingan Jiang, Mengfei Zhu, Lijun Chen, Xiaoyang Zhou, Chenliang Zhou, Peng Ye, Xiaobei Chen, Baohong Wang, Zhenyu Xu, Qiang Zhang, Xiaowei Xu, Hainv Gao, Xiaojun Wu, Dong Li, Wanli Jiang, Jingjing Qu, Charlie Xiang, Lanjuan Li
《医学前沿(英文)》 2020年 第14卷 第5期 页码 664-673 doi: 10.1007/s11684-020-0810-9
关键词: coronavirus disease 2019 (COVID-19) mesenchymal stem cell acute respiratory distress syndrome stem cell therapeutics
一款用于快速检测包括SARS-CoV-2 在内的19 种常见呼吸道病毒的高通量、多指标等温扩增平台 Article
邢婉丽,刘莹莹,王会丽,李尚霖,林勇平,陈蕾,赵艳,晁爽,黄小兰,葛少林,邓涛,赵添,李宝莲,王瀚博,王磊,宋云鹏,金荣华,何建行,赵秀英,刘鹏,李为民,程京
《工程(英文)》 2020年 第6卷 第10期 页码 1130-1140 doi: 10.1016/j.eng.2020.07.015
快速、准确地诊断以及及时对感染严重急性呼吸系统综合征冠状病毒2(SARS-CoV-2)的患者进行隔离被认为是抗击新冠病毒肺炎(COVID-19)大流行的最有效的措施。本文介绍了一款高通量、多指标的等温扩增检测平台(RTisochipTM-W),该平台使用离心式微流控芯片,在90 min内即可完成一次运行,从16个样本中检测出包括SARS-CoV-2在内的19种常见呼吸道病毒。通过RTisochipTM-W系统检测的所有病毒的检出限均等于或小于50拷贝· μL−1,与常规逆转录聚合酶链反应(RT-PCR)灵敏度相当。该系统具有重复性好、鲁棒性强和特异性高的优点。最后,使用RTisochipTM-W系统对201例临床前样本、14例COVID-19阳性临床样本、25例临床确诊样本以及614例来自呼吸道感染或疑似感染的患者的临床样本进行了测试。测试结果与临床诊断结果吻合良好,也反映出呼吸道传染病的流行特征。在对SARS-CoV-2的诊断上,RTisochipTM-W系统与参考试剂盒的一致性达到98.15%。基于大量的测试结果,我们相信RTisochipTM-W系统是一款抗击COVID-19大流行的强有力工具。
关键词: COVID-19 SARS-CoV-2 微流控 核酸检测 等温扩增
Treatment of severe acute pancreatitis through retroperitoneal laparoscopic drainage
Chun Tang, Baolin Wang, Bing Xie, Hongming Liu, Ping Chen
《医学前沿(英文)》 2011年 第5卷 第3期 页码 302-305 doi: 10.1007/s11684-011-0145-7
关键词: severe acute pancreatitis (SAP) laparoscope retroperitoneal drainage treatment
Epidemiology, pathogenesis, and management of coronavirus disease 2019-associated stroke
《医学前沿(英文)》 doi: 10.1007/s11684-023-1041-7
关键词: SARS-CoV-2 ischemic stroke stroke hemorrhagic stroke cerebral venous thrombosis vaccination
《医学前沿(英文)》 2022年 第16卷 第3期 页码 389-402 doi: 10.1007/s11684-021-0856-3
关键词: severe community-acquired pneumonia lung microbiota clinical improvements 7-category ordinal scale Prevotellaceae
Atypical manifestations of acute coronary syndrome — throat discomfort: a multi-center observational
《医学前沿(英文)》 2022年 第16卷 第4期 页码 651-658 doi: 10.1007/s11684-021-0859-0
关键词: acute coronary syndrome (ACS) throat discomfort (TD) throat pain cardiology departments non-cardiologic physicians
标题 作者 时间 类型 操作
A pilot study on Paxlovid therapy for hemodialysis patients with severe acute respiratory syndrome coronavirus
期刊论文
Clinical characteristics of 19 neonates born to mothers with COVID-19
Wei Liu, Jing Wang, Wenbin Li, Zhaoxian Zhou, Siying Liu, Zhihui Rong
期刊论文
Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns
null
期刊论文
Clinical manifestations and pathogen characteristics in children admitted for suspected COVID-19
Xiaofang Cai, Hanlan Jiang, Simin Zhang, Shengying Xia, Wenhui Du, Yaoling Ma, Tao Yu, Wenbin Li
期刊论文
Middle East respiratory syndrome coronavirus in pediatrics: a report of seven cases from Saudi Arabia
Sarah H. Alfaraj, Jaffar A. Al-Tawfiq, Talal A. Altuwaijri, Ziad A. Memish
期刊论文
Early and marked up-regulation of TNF-α in acute respiratory distress syndrome after cardiopulmonary
null
期刊论文
Clinical study using mesenchymal stem cells for the treatment of patients with severe COVID-19
Lingling Tang, Yingan Jiang, Mengfei Zhu, Lijun Chen, Xiaoyang Zhou, Chenliang Zhou, Peng Ye, Xiaobei Chen, Baohong Wang, Zhenyu Xu, Qiang Zhang, Xiaowei Xu, Hainv Gao, Xiaojun Wu, Dong Li, Wanli Jiang, Jingjing Qu, Charlie Xiang, Lanjuan Li
期刊论文
一款用于快速检测包括SARS-CoV-2 在内的19 种常见呼吸道病毒的高通量、多指标等温扩增平台
邢婉丽,刘莹莹,王会丽,李尚霖,林勇平,陈蕾,赵艳,晁爽,黄小兰,葛少林,邓涛,赵添,李宝莲,王瀚博,王磊,宋云鹏,金荣华,何建行,赵秀英,刘鹏,李为民,程京
期刊论文
Treatment of severe acute pancreatitis through retroperitoneal laparoscopic drainage
Chun Tang, Baolin Wang, Bing Xie, Hongming Liu, Ping Chen
期刊论文
Clinical factors associated with composition of lung microbiota and important taxa predicting clinicalprognosis in patients with severe community-acquired pneumonia
期刊论文